Thinking about a GLP-1? Get two numbers before you sign up: what it costs to start and what it costs to refill the same medication. That low monthly price in the ad might only cover a starter dose, reflect a bundle you pay for upfront, or depend on a manufacturer offer.
Semaglutide and tirzepatide, in plain English
Semaglutide acts on a hormone receptor called GLP-1. Tirzepatide acts on GLP-1 and GIP receptors. Both signals play a part in appetite and blood sugar. In clinical trials, FDA-approved weight-management products helped eligible patients lose weight alongside diet and activity changes. Your response depends on the product, dose, side effects and whether you can stay on treatment.
Wegovy and Zepbound have FDA-approved weight-management uses. A clinician checks the exact product label, weight-related conditions, medicines, pregnancy plans and medical history. For many adult weight-management indications, evaluation starts at a BMI of 30, or 27 with a weight-related condition. Other indications and populations have their own criteria.
What’s the difference between FDA-approved and compounded GLP-1s?
The FDA doesn’t review compounded products for safety, effectiveness, or quality before they go on the market. FDA has declared the injection shortages resolved, and regular compounding of essentially copies is restricted. A prescriber may document a significant difference for an identified patient when applicable. Ask why an FDA-approved option cannot meet your needs, which pharmacy fills the prescription, and what concentration and measuring instructions apply. FDA has received reports of dosing errors with compounded injectable products.
Side effects and who to call
Nausea, constipation, diarrhea and vomiting can occur. Review warnings about pancreatitis, gallbladder problems and dehydration, and tell your clinician if you take insulin or medicines that can lower blood sugar. The product labels carry a thyroid tumor warning and include restrictions for certain personal or family histories. Ask who helps if symptoms persist, you miss several doses, or you receive a shipment that arrives warm.
What do semaglutide and tirzepatide cost without insurance?
When you compare prices, line up the medication, form, dose, and number of days it covers. Ask for the checkout price, the next dose-tier price, and any charges for labs, a membership, delivery or follow-up. Check the manufacturer’s current cash price for the exact FDA-approved product and whether you meet offer conditions.
What GobyMeds charges for GLP-1s
| Product | Starter or monthly price | Continuing price examples |
|---|---|---|
| Compounded semaglutide injection | $299 for the 12-week starter | $199 single month on the treatment page. The 12-week list spans $299–$499 by dose. |
| Compounded tirzepatide injection | $399 for the 12-week starter | $299 single month. The treatment page lists $499–$599 for 12-week continuing options. |
| Wegovy and Zepbound branded injections | $1,695 and $1,399 per month, respectively | Confirm dose, exact pen and checkout quote. |
GobyMeds says its GLP-1 plans include the online visit, provider follow-up, injection supplies and refrigerated shipping. It advertises no membership and no automatic refills. Intake may require photo ID, a clothed photo, or documentation of recent medication use for a higher starting dose. Ask whether labs or a live visit are needed for your case and whether your product is available in your state.
GobyMeds says you place reorders manually in the portal. Confirm the next dose and price before your supply runs low. Its billing policy says pharmacy preparation and shipping take business days after approval and can vary. Review the cancellation stages in our GobyMeds review before placing an order.
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Questions to ask before ordering
Does $99 or $133 mean monthly billing?
Those prices show what the 12-week starter bundles work out to per month. With the standard order process, you pay for the whole bundle at once if you’re approved.
What if the clinician changes my plan?
GobyMeds says it refunds the difference if the approved bundle costs less and asks you to approve an extra charge before pharmacy submission if it costs more.
Compare the same drug across billing models in our provider comparison.
More on GLP-1 costs and refills
- Compare cash prices for tirzepatide without insurance
- See Wegovy tablet and pen cash prices
- See how GobyMeds refills and reorders work
Related reading
- GobyMeds Starter vs. Continuing GLP-1 Prices
- How to Compare GLP-1 Clinic Membership Fees
- What to Bring When You Switch GLP-1 Providers
Sources
Provider prices and terms checked November 12, 2026.
- GobyMeds weight-loss plans
- GobyMeds price list
- GobyMeds billing policy
- FDA compounding policy
- FDA safety concerns for unapproved GLP-1 products